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SYNTHESIS, CHARACTERIZATION AND BIOLOGICAL STUDY OF PIPERIDINE DERIVATIVES
2
Author(s):
P.CHANTIBABU, R.S.K.SHARMA
Vol - 3, Issue- 1 ,
Page(s) : 199 - 204
(2012 )
DOI : https://doi.org/10.32804/CASIRJ
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Abstract
The piperidine ring is a structural feature of many alkaloids and drug candidates and there were thousands of piperidine compounds mentioned in clinical and preclinical studies. The piperidine ring system is one of the commonest structural sub units in natural compounds. Several substituted piperidines display important biological properties like antiviral activity. Thus, in this study some novel piperidine derivatives were synthesized in order to observe their probable Anticholinesterase effects. Structures of obtained compounds were confirmed by IR, NMR and Mass spectroscopic methods. Anticholinesterase activities of the synthesized compounds were tested by using Ellman’s method. Some of the compounds in the series indicated good enzyme inhibitory activity.
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