Azadirachta indica, Aloe vera, Elettaria cardamomum, Curcuma longa, Coriandrum sativum, Emblica officinalis are common medicinal plantsused in traditional Indian medicine for the treatment of various diseases. These plants were selected to evaluate their potential antimicrobial activity.The antimicrobial activities and phytochemicals in crude methanolic extractsof six medicinal plants used in Indian medicine were determined byagar well diffusion and broth dilution techniques against gram-positive bacteria (Bacillus amyloliquefaciens and Staphylococcus aureus) and gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa).The antimicrobial activities of the extracts were inferred by the diameter of zone of inhibition against test strains. Results showed that the methanolic extract of Aloe vera exhibited significant antibacterial activity against gram-positive and gram-negative strains. . The methanolic extract of the Aloe vera showed the inhibition having maximum antimicrobial activity against S.aureus and P.aeruginosa showing 15mm zone of inhibition .The presence of phytochemicals such as Flavonoids, terpenoids, tannins, reducing sugars, soluble phenols,saponin, alkaloids, steroids and glycosides in the extracts of these plants supports their traditional uses as medicinal plants for the treatment of various diseases. The present study reveals potential use of these plants for developing new antibacterial compounds against pathogenic microorganisms.