The word immunity means the state of protection from infectious disease. The immune system evolved as defense system to protect animals from invading microorganisms and malignant disorders. Immunology is a branch of biomedical science that covers the study of all aspects of the immune response in all organisms. The study of the molecular and cellular components that comprise the immune system, including their function and interaction, is the central science of immunology. Ayurvedic system of medicine not only deals with treating the diseases but also aims to prevention the disease. Vyadhikshamatva (Immunity) is described in Ayurveda and this concept is considered equivalent to immunity. Hence an attempt has been made to present Ayurvedic concepts of immunity and immunization in the pandemic situation of COVID-19. This pandemic has turned the world’s attention to immune system. Ayurveda has been a trusted measure in the fight of against coronavirus. The extensive knowledge base of Ayurveda on preventive care derives from the concepts daily regimes and seasonal regimes that are the key to healthy life.