International Research Journal of Commerce , Arts and Science

 ( Online- ISSN 2319 - 9202 )     New DOI : 10.32804/CASIRJ

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SYNTHESIS AND STUDY OF THERAPEUTIC POTENTIAL OF SOME NEW CINNOLINE BASED CHALCONES AND CINNOLINE BASED PYRAZOLINE DERIVATIVES

    1 Author(s):  DR. RINKY KUMARI

Vol -  11, Issue- 10 ,         Page(s) : 18 - 24  (2020 ) DOI : https://doi.org/10.32804/CASIRJ

Abstract

4-Methyl-3-acetyl cinnoline is used as starting material to synthesize some new cinnoline based chalcones 2(a-l). Reaction of chalcone with hydrazine hydrate in acetic acid yields the cinnoline based pyrazoline derivatives 3(a-l). The structures of synthesized compounds have been confirmed by elemental analysis, IR and NMR spectral studies and evaluated for their antifungal activity against Aspergillus flavus, Fusarium oxysporum, Aspergillus niger, Trichoderma viridaeand antibacterial activity against Bacillus subtilis, Escherichia coli, Staphylococcus aureausand Klebsiella pneumoniae, and insecticidal activityevaluated against cockroach (Periplaneta Americana).

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