International Research Journal of Commerce , Arts and Science

 ( Online- ISSN 2319 - 9202 )     New DOI : 10.32804/CASIRJ

Impact Factor* - 6.2311


**Need Help in Content editing, Data Analysis.

Research Gateway

Adv For Editing Content

   No of Download : 33    Submit Your Rating     Cite This   Download        Certificate

SYNTHESIS AND BIOLOGICAL SCREENING OF SOME NEW PYRAZOLINES DERIVATIVES AS STUDY OF ANTIBACTERIAL AND ANTI-INFLAMATORY ACTIVITY

    1 Author(s):  DR. SANJAY KUMAR

Vol -  11, Issue- 10 ,         Page(s) : 11 - 17  (2020 ) DOI : https://doi.org/10.32804/CASIRJ

Abstract

To get the pyrazolines derivatives (P-1 to P-14), the chalcones were prepared from substituted acetophenones and substituted benzaldehydes and condensed with hydrazine hydrate in ethanol. The new compounds were synthesized and characterizes by TLC, melting points, IR, and 1H-NMR spectra. All the synthesized compounds were screened for their antibacterial and anti-inflammatory activities. The in vitro antibacterial activity was checked against two Gram positive microorganisms (S. aureus and B. subtilis) and two Gram negative microorganisms (E. coli and P. aureginosa). Some of tested compounds exhibited promising antibacterial and anti-inflammatory activities.

Mann F., Chiment F., Balasco A., Cenicola M.L.,AmicoM.D.,ParriloC.,RossiF.,Marmo E.: Eur. J. Med. Chem. 27, 633(1992).
Amir M., Kumar S.: Indian J. Chem. 44B, 2532 (2005).
Desai J.M., Shah V.H.: Indian J. Chem. 42B, 382(2003).
FahmyA.M.,HassaK.M.,KhalafA.A.,Ahmed R.A.: Indian J. Chem., 26, 884(1987).
Nugent R.A., Murphy M., SchlachterS.T., Dunn C.J. Smith R.J. Staite L.A. et al.: J. Med. Chem. 36, 134(1993).
Rangari V., Gupta V. N., Atal C.K.: Indian J. Pharm. Sci. 52, 158(1990).
Husain M. I., Shukla S.: Indian J. Chem., 25, 983(1986).
Rich S., Horsfall J. G.: Chem. Abst., 46, 11543 (1952).

*Contents are provided by Authors of articles. Please contact us if you having any query.






Bank Details